Our research aims to explore fundamental problems at the interface of Chemistry and Biology, particularly in the areas of bimolecular recognition and sensing, through a multidisciplinary approach involving a combination of chemical synthesis, biophysical and biochemical methods, and computational chemistry. More specifically, our work has focused on three main topics:
The synergistic integration of coordination chemistry and peptide engineering to construct new supramolecular assemblies with biological activity, particularly new DNA-binding agents that target non-canonical structures (G-quadruplex and three-way junctions).
The development of new fluorescent probes for the specific detection of relevant biomolecules (e.g, RNA, oncoproteins, kinases), as well as cellular processes.
e-Prot project, which mist to the rational design of efficient conductive protein systems (e-Ps), and the fabrication of all-protein based conductive structures and materials, targeting a radical change in design of "green" electronic and energy storage devices